血小板致动脉粥样硬化作用机制的研究进展

Mechanisms of platelets induced atherosclerosis:research progress

血小板是由骨髓巨核细胞生成的一类重要血细胞,主要参与机体止血、凝血、血栓形成及器官移植排斥等,且在维持机体血管损伤修复平衡、保持内环境稳定等方面起重要作用。血小板还可与多种细胞及因子结合,参与级联炎症反应,促进动脉粥样硬化形成。血小板通过各种表面受体、胞内信号转导分子、多种细胞因子实现其功能。血小板及相关分子的研究和应用,对于阐述动脉粥样硬化病变的发生机制十分重要,在监测心血管事件的发生发展中具有潜在的应用前景。

Platelets are important blood cells,which are derived from bone marrow megakaryocytes,mainly involved in hemostasis,coagulation,thrombosis,graft rejection,maintaining vasculature balance,and maintaining homeostasis.Platelets are also associated with a variety of cells and cytokines and are involved in cascade inflammatory responses,and then promote the formation of atherosclerosis.The functions of platelets are achieved by a variety of surface receptors,intracellular signal transduction molecules,and a variety of cytokines.The research and application of platelets and related molecules are very important to elucidate the pathogenesis of atherosclerosis,and have potential application prospects in monitoring the occurrence and development of cardiovascular events.