脂肪来源干细胞在慢性创面愈合中作用的研究进展

Effect of adipose-derived stem cells in chronic wound healing:research progress

慢性创面难愈或不愈是目前整形外科亟待解决的难题。脂肪来源干细胞(adipose-derived stem cells,ADSCs)除具有与其他间充质来源干细胞类似的性质外,还具有取材方便、来源充足及体型雕塑等优点,成为近年来再生医学领域的研究热点。大量研究表明,ADSCs可通过多种机制促进慢性创面愈合,被认为是一种非常有前景的治疗策略。因此,本文就ADSCs的分离纯化及其在慢性创面修复中的作用机制等作一综述。

Chronic wound is a major challenge in plastic surgery and the whole medical field.The way to promote wound healing is a matter to be solved urgently.Adipose-derived stem cells（ADSCs）,compared to other mesenchymal stem cells,have the advantages of convenient material,adequate source and poise sculpture,and have become a hotspot in the field of regenerative medicine in recent years.A large number of studies have shown that ADSCs can promote chronic wound healing through a variety of mechanisms and are considered to be a promising treatment strategy.In this paper,the isolation and purification,the mechanism and application of ADSCs in chronic wounds were reviewed.