腹腔镜胃癌根治术辅助热灌注化疗治疗进展期胃癌疗效分析

Analysis on Curative Effect of Laparoscopic Radical Gastrectomy Combined with Hyperthermic Perfusion Chemotherapy in the Treatment of Advanced Gastric Cancer

目的分析腹腔镜胃癌根治术辅助热灌注化疗治疗进展期胃癌的疗效。方法选取我院2012年5月至2014年5月收治的78例进展期胃癌患者,随机平均分为对照组和实验组。对照组仅采取腹腔镜胃癌根治术治疗,实验组行腹腔镜胃癌根治术后再给予热灌注化疗。比较两组患者的疗效。结果两组患者的胃肠道功能恢复时间、术后住院时间、Ⅱ期复发率及Ⅱ期生存率比较差异无统计学意义(P>0.05)。实验组的并发症发生率和Ⅲ期复发率均明显低于对照组,Ⅲ期生存率高于对照组(P<0.05)。结论腹腔镜胃癌根治术辅助热灌注化疗治疗进展期胃癌的术后并发症发生率和复发率较低,生存率较高,疗效显著,安全可靠。

Objective To analyze the curative effect of laparoscopic radical gastrectomy combined with hyperthermic perfusion chemotherapy in the treatment of advanced gastric cancer. Methods 78 cases of patients with advanced gastric cancer admitted to our hospital from May 2012 to May 2014 were selected and randomly divided into control group and experimental group equally. The control group only received laparoscopic radical gastrectomy, while the experimental group received hyperthermic perfusion chemotherapy after laparoscopic radical gastrectomy. The curative effect was compared between the two groups. Results No statistical difference was found in the recovery time of gastrointestinal function, postoperative hospitalization time, phase II recurrence rate and phase II survival rate between the two groups （P 〉0.05）. The complication incidence and phase III recurrence rate of the experimental group was significantly lower than that of the control group, and the phase III survival rate was higher than that of the control group （P 〈0.05）. Conclusions Laparoscopic radical gastreetomy combined with hyperthermic perfusion chemotherapy in the treatment of advanced gastric cancer has lower incidence of postoperative complications and recurrence rate, higher survival rate, and significant curative effect, which is safe and reliable.