小剂量螺内酯联合常规治疗对慢性充血性心力衰竭的效果

Effect of Low-Dose Spironolactone Combined with Conventional Treatment on Chronic Congestive Heart Failure

目的观察小剂量螺内酯联合常规治疗对慢性充血性心力衰竭的效果。方法选取我院2014年4月至2016年5月收治的200例慢性充血性心力衰竭患者,随机分为对照组和观察组,各100例。对照组行常规治疗,观察组在此基础上加用小剂量螺内酯。比较两组患者的心功能指标、治疗效果、BNP和ET水平。结果治疗后,观察组的总有效率为95.0%,明显高于对照组的85.0%(P<0.05)。入院时两组患者的心功能指标、BNP和ET水平比较差异无统计学意义(P>0.05)。治疗后,观察组的心功能指标、BNP和ET水平均优于对照组(P<0.05)。结论对慢性充血性心力衰竭采用小剂量螺内酯联合常规治疗,治疗效果较好,能够明显改善心功能。

Objective To observe the effect low-dose spironolactone combined with conventional treatment on chronic congestive heart failure. Methods 200 cases of patients with chronic congestive heart failure admitted to our hospital from April 2014 to May 2016 were selected and randomly divided into control group and observation group, with 100 cases in each group. The control group received conventional treatment, while the observation group received low-dose spironolactone on this basis. The indicators of cardiac function, treatment effect, BNP and ET levels were compared between two groups. Results After treatment, the total effective rate of observation group was 95.0%, significantly higher than 85.0% of control group （P〈0.05）. No statistical difference was found in the indicators of cardiac function, BNP and ET levels on admission between two groups （P〉0.05）. After treatment, the indicators of cardiac function, BNP and ET levels of observation group were better than those of control group （P 〈0.05）. Conclusions Low-dose spironolactone combined with conventional treatment on chronic congestive heart failure has better treatment effect, and can improve the cardiac function.