间歇性及连续性蓝光照射治疗新生儿黄疸的疗效及安全性对比研究

Comparative Study on the Curative Effect and Safety of Intermittent and Continuous Blue Light Irradiation in the Treatment of Neonatal Jaundice

目的对比间歇性及连续性蓝光照射治疗新生儿黄疸的疗效与安全性。方法选取我院2015年8月至2016年8月收治的118例黄疸新生儿,随机分为两组。Ⅰ组采用间歇性蓝光照射,Ⅱ组采用连续性蓝光照射。比较两组患儿的临床指标(血清胆红素、粪胆素)、不良反应及疗效。结果两组患儿的临床指标比较差异无统计学意义(P>0.05)。Ⅰ组的不良反应发生率明显低于Ⅱ组,差异有统计学意义(P<0.05)。两组患儿的总有效率比较差异无统计学意义(P>0.05)。结论采用间歇性和连续性蓝光照射治疗新生儿黄疸均有明显的效果,而间歇性蓝光照射的不良反应发生率较低,更适用于新生儿。

Objective To compare the curative effect and safety of intermittent and continuous blue light irradiation in the treatment of neonatal jaundice. Methods 118 cases of patients with neonatal jaundice admitted to our hospital from August 2015 to August 2016 were selected and randomly divided into two groups. The group I received intermittent blue light irradiation, while the group II received continuous blue light irradiation. The clinical indicators （serum bilirubin, fecal bile）, adverse reactions and curative effect were compared between two groups. Results No statistical difference was found in the clinical indicators between two groups （P〉0.05）. The incidence of adverse reactions of group I was significantly lower than that of group II, with statistical difference （P〈0.05）. No statistical difference was found in the total effective rate between two groups （P〉0.05）. Conclusions Both intermittent and continuous blue light irradiation have significant effect in the treatment of neonatal jaundice. But intermittent blue light irradiation has lower incidence of adverse reactions, which is more suitable for uewbom babies.