缩宫素联合米索前列醇和钙剂预防及治疗产后出血的临床分析

Clinical Analysis on Oxytocin Combined with Misoprostol and Calcium in the Prevention and Treatment of Postpartum Hemorrhage

目的探讨缩宫素联合米索前列醇与钙剂预防和治疗产后出血的临床疗效。方法选取我院收治的200例产妇,随机分为两组。A组使用缩宫素联合米索前列醇、钙剂治疗,B组仅在胎儿娩出后使用缩宫素进行宫体注射。比较两组患者的出血量、术后不良反应发生率和总有效率。结果 A组的出血量显著少于B组(P<0.05)。A组的术后不良反应发生率显著低于B组(P<0.05)。A组的总有效率为99.0%,显著高于B组的93.0%(P<0.05)。结论缩宫素联合米索前列醇可在短时间内促进子宫收缩,快速止血,且不良反应发生率低。钙剂能够提高子宫对缩宫素的敏感性,进一步增强子宫收缩并促进凝血。

Objective To explore the clinical curative effect of oxytocin combined with misoprostol and calcium in the prevention and treatment of postpartum hemorrhage. Methods 200 cases of puerperas admitted to our hospital were selected and randomly divided into two groups. Group A was treated with oxytocin, misoprostol and calcium, while group B only received oxytocin for uterine injection after after delivery of fetus. The blood loss, incidence of postoperative adverse reactions and total effective rate were compared between two groups. Results The blood loss of group A was significantly less than that of group B （P 〈0.05）. The incidence of adverse reactions of group A was significantly lower than that of group B （P 〈0.05）. The total effective rate of group A was 99.0%, significantly higher than 93.0% of group B （P〈0.05）. Conclusions Oxytocin combined with misoprostol can promote the uterine contraction in a short time, and stop bleeding rapidly, with low incidence of adverse reactions. Calcium can improve the sensitivity of uterus to oxytocin, further enhance uterine contraction and promote coagulation.