复方甘草酸苷在白癜风合并淋病患者中的应用及对红细胞免疫指标的影响

Application of compound glycyrrhizin in patients with vitiligo complicated with gonorrhea and the effect on erythrocyte immune index

目的:旨对复方甘草酸苷在白癜风合并淋病患者中的应用及对红细胞免疫指标的影响进行探究分析。方法:选择我院2014年1月至2016年6月间收治的36例白癜风合并淋病为研究资料;在常规抗生素(头孢地嗪钠1g,1次/d)治疗基础上,辅以复方甘草酸苷治疗,2片/次,3次/d;治疗时间为4周。观察36例研究资料的治疗前后红细胞免疫指标:免疫粘附促进因子(FEER)、免疫粘附抑制因子(FEIR)、免疫复合物(CIC)、直向肿瘤红细胞免疫花环率(DTER)检测水平及临床治疗有效率。结果:经4周治疗后,36例患者红细胞免疫指标检测水平明显优于治疗前(P<0.05),差异具统计学意义,且临床治疗有效率高达88.9%(32/36)。结论:尽管白癜风合并淋病患者的红细胞免疫指标水平均呈现相对较差的状态,但复方甘草酸苷则可以有效改善白癜风合并淋病患者红细胞免疫指标水平;因此,临床采用复方甘草酸苷治疗白癜风合并淋病具有良好的临床应用价值。

Objectives： To investigate the effects of compound glycyrrhizin on patients with vitiligo complicated with gonorrhea and the influence on erythrocyte immune index. Methods： 36 vitiligo patients with gonorrhea treated in our hospital from January 2014 to June 2016 were selected. Based on the treatment of conventional antibi-otics（ cefodizime sodium 1 g,1 time/d）,compound glycyrrhizin treatment was conducted,2 tablets/time,3 times/d for 4 weeks. The levels of erythrocyte immune index（ FEER）,immunosuppressive factor（ FEIR）,immunocomplex（ CIC）,and erythrocyte immune rosette rate（ DTER） were measured before and after treatment. Clinical treatment efficiency was analyzed. Results： After 4 weeks of treatment,the levels of erythrocyte immune indexes in 36 patients were significantly higher than those before treatment（ P 0. 05）,with statistically significant difference（Table 1）,and the clinical treatment rate was 88. 9%（32/36）. Conclusion： Although the levels of erythrocyte immune indexes in patients with vitiligo and gonorrhea are relatively poor,compound glycyrrhizin can effectively improve the level of erythrocyte immune index in patients with vitiligo complicated with gonorrhea. Therefore,the clinical use of compound glycyrrhizin to treat vitiligo with gonorrhea has good clinical application value.