苄星青霉素与阿奇霉素治疗早期梅毒的临床对比研究

Clinical study on effect of benzathine benzylpenicillin and azithromycin in the treatment of early syphilis

目的:探讨苄星青霉素和阿奇霉素治疗早期梅毒疗效比较,以期提高治疗水平。方法:按入院时住院号单双选取2010年9月至2015年9月116例早期梅毒患者为研究对象,分成两组,每组均为58例,分别予苄星青霉素和阿奇霉素治疗,观察治疗后在皮损愈合时间、甲苯胺红非加热血清试验(Toluidine red unheated serum test,TRUST)转阴率、T淋巴细胞亚群变化情况。结果:两组治疗后在平均皮损起效时间、平均皮损痊愈时间和治疗后1个月、3个月、6个月、9个月、12个月梅毒TRUST转阴率比较差异无统计学意义(P均>0.05);两组治疗后CD3^+、CD4^+、CD8^+、CD4^+/CD8^+均明显改善,除CD8^+外均显著升高,CD8^+则显著下降,组内比较差异显著(P<0.05),但两组治疗后CD3^+、CD4^+、CD8^+、CD4^+/CD8^+比较差异不显著(P均>0.05)。结论:苄星青霉素和阿奇霉素均是治疗早期梅毒良好药物,对青霉素过敏者可选择阿奇霉素。

Objectives： To study the effect of benzathine benzylpenicillin and azithromycin in the treatment of early syphilis,in order to improve the level of treatment. Methods： According to the single and double admission number,116 cases of early syphilis from September 2010 to September 2015 were divided into two groups,with 58 cases in each group. The two groups received benzathine penicillin and azithromycin treatment respectively. The skin lesion healing time,TRUST negative conversion ratio（ Toluidine red unheated serum test,TRUST）,and the changes of T lymphocyte subgroup were observed. Results： The average skin lesion onset time,average skin healing time,and 1 month,3 months,6 months,9 months,12 months after treatment syphilis TRUST negative conversion ratio in the two groups after treatment had no statistically significant difference（ P 0. 05）. After treatment,CD3~＋,CD4~＋,CD8~＋,CD4~＋/CD8~＋were significantly improved. In addition to CD8~＋,the others were significantly increased,and CD8~＋was significantly decreased,（ P 0. 05）. CD3~＋,CD4~＋,CD8~＋,CD4~＋/CD8~＋in two groups after treatment had no significant difference（ P 0. 05）. Conclusion： Benzathine penicillin and azithromycin are good drugs in the treatment of early syphilis. Patients who are allergic to penicillin can choose azithromycin for treatment.