摘要
IgA肾病(IgAN)是全球范围内最常见的原发性肾小球疾病之一,近年来在儿童中的患病率明显升高,部分患儿最终发展为终末期肾病(ESRD),对儿童的生活质量及生命造成了严重威胁;由于其发病机理尚不明确,以及临床表现的多样性和预后的差异性,在临床上尚无疗效确切公认的治疗方法,药物治疗是常用的治疗手段。细胞凋亡是细胞生命活动中的基本现象,是近年生命科学研究的热点。该文对IgAN中有关细胞凋亡的研究进展进行综述,指出对细胞凋亡的干预可能是一种对IgAN新的治疗靶点。
IgA nephropathy（ IgAN） is one of the most common primary glomerular disease in the world. In recent years,the incidence of it increases significantly in children,and some children eventually develop into end-stage renal disease which threatens the quality of life and life itself seriously. The pathogenesis is not clear,and there is no definite treatment in clinics because of the diversity of clinical manifestations and prognosis. Drug therapy is commonly used in treatment. Apoptosis is the basic phenomenon in cell life activities,and also it is a hot topic in today＇s life science research. This paper summarized research progress of apoptosis in IgAN and proposed that apoptosis intervention might be a new therapeutic target for IgAN.
出处
《中国妇幼健康研究》
2017年第10期1275-1277,共3页
Chinese Journal of Woman and Child Health Research
关键词
IGA肾病
细胞凋亡
抑制凋亡
促进凋亡
IgA nephropathy （IgAN）
apoptosis
inhibit apoptosis
promote apoptosis
