莫西沙星联合阿奇霉素治疗小儿支原体肺炎的临床疗效分析

Clinical analysis of Moxifloxacin combined with Azithromycin in treatment of mycoplasma pneumonia in children

目的对小儿支原体肺炎患儿采用莫西沙星联合阿奇霉素进行治疗,分析其临床治疗效果。方法选取临颍县人民医院2010年1月至2015年5月接收治疗的240例小儿支原体肺炎按治疗方式不同随机分为对照组和治疗组,每组各120例,对照组采用阿奇霉素进行治疗,治疗组患者在此基础上加用莫西沙星进行治疗,治疗后比较两组患儿的咳嗽消失时间、肺部罗音消失时间、退热时间以及治疗总有效率。结果治疗后,治疗组患儿的咳嗽消失时间、肺部罗音消失时间以及退热时间分别为(4.74±0.51)d、(4.11±0.47)d、(1.99±0.49)d,显著优于对照组的(5.17±0.62)d、(4.82±0.46)d、(2.71±0.13)d,差异具有统计学意义(P<0.05)。治疗组总有效率达90.83%,对照组总有效率为75%,两组差异具有统计学意义(P<0.05)。结论小儿支原体肺炎可采用莫西沙星联合阿奇霉素进行治疗,其治疗疗效显著,可显著提高患儿症状改善速度,具有一定的临床推广应用价值。

Objective To investigate the clinical effect of moxifloxacin combined with azithromycin for treatment mycoplasma pneumonia in children. Methods Totally 240 cases children patient in our hospital from 2010 Jan to 2015 May were divided into the treatment group（ TG,n = 120） and control group（ CG,n = 120） according to the treatment. CG was treated by azithromycin,TG were treated by Moxifloxacin on the basis of CG. After treatment,two groups cough disappeared time,lung rale disappearing time,antifebrile time and total effective treatment were compared. Results After treatment,cough disappeared time,lung rale disappearing time,antifebrile time of the treatment group were significantly better than those the control group（ P〈0. 05）,total effectiveness of the treatment group was 90. 83%,total effective rate of control group was 75%,the difference between the two groups have statistical significance（ P〈0. 05）.Conclusion Moxifloxacin combined with azithromycin in the treatment of mycoplasma pneumoniae infection among children is effectively,can significantly improve the symptoms improved speed. It is worthy of clinical popularization.