骨痨愈康丸联合来氟米特治疗类风湿关节炎临床观察

Clinical Observation of Gulaoyukang Pill Combined with LEF for RA

目的:观察运用骨痨愈康丸联合来氟米特(LEF)治疗类风湿关节炎(RA)的临床疗效及相关实验室检查指标的变化情况。方法:将80例患者随机分为对照组和治疗组各40例,对照组单用来氟米特治疗。治疗组在此基础上加用骨痨愈康丸。治疗3月后评价2组临床疗效,并观察其炎症指标:血沉(ESR)、C-反应蛋白(CRP)、类风湿因子(RF)及免疫指标免疫球蛋白A(IgA)、免疫球蛋白M(IgM)、免疫球蛋白G(IgG)、补体C3、补体C4等实验室指标的变化。结果:2组临床疗效比较,总有效率治疗组92.31%,对照组84.21%,差异有统计学意义(P<0.05)。治疗后,2组炎症指标ESR、CRP、RF分别与治疗前比较,差异均有统计学意义(P<0.05,P<0.01);治疗后,炎症指标ESR、CRP、RF治疗组治疗前后差值分别与对照组比较,差异均有统计学意义(P<0.05)。治疗后,2组免疫指标IgG、C3、C4,治疗组IgM等分别与治疗前比较,差异均有统计学意义(P<0.05,P<0.01);对照组IgA、IgM,治疗组IgA分别与治疗前比较,差异均无统计学意义(P>0.05);治疗后,治疗组IgA、IgM、C3、C4治疗前后差值分别与对照组比较,差异均有统计学意义(P<0.05)。结论:骨痨愈康丸联合来氟米特治疗类风湿关节炎,临床疗效良好,无明显不良反应。

Objective：To observe the clinical effect of Gulaoyukang pill combined with Leflunomide（LEF） for Rheumatoid arthritis（RA） and the change of relevant indexes. Methods：Divided 80 patients into the control group and the treatment group being 40 cases in each. The control group was treated with oral LEF,while the treatment group was given oral Gulaoyukang pills,based on the treatment of the control group. After three weeks of treatment,evaluated clinical effect of both groups,and observed change of erythrocyte sedimentation rate（ESR）,C-reactive protein and rheumatoid factors（RF）,immunoglobulin A（IgA）,immunoglobulin M（IgM）,immunoglobulin G（IgG）,complement C3 and complement C4. Results：The total effective rate was 92.31% in the treatment group,and was 84.21% in the control group,the difference being significant（P0.05）.After treatment,compared ESR,CRP and RF of both groups with those before treatment respectively,differences being significant（P0.05,P0.01）. Compared differences of ESR,CRP and RF of the two groups before and after treatment,there were significant differences（P0.05）. After treatment,compared IgG、C3、C4 of both groups and IgM of the treatment group with those before treatment,differences being significant（P0.05,P0.01）. Compared IgA and IgM of the control group, and Ig Aof the treatment group with those treatment, the differences had no significant difference（P 0.05）.Compared difference of IgA,IgM,C3 and C4 of the two groups before and after treatment,differences being significant（P0.05）. Conclusion：Gulaoyukang pill combined with LEF has good clinical efficacy and no obvious adverse reaction in treating RA.