右美托咪定在全身麻醉中的应用

Application of dexmedetomidine in general anesthesia

目的:分析右美托咪定在全身麻醉中的应用效果。方法:选择2016年3月至2017年4月间进行手术的300例患者为研究对象,随机分为观察组与对照组,每组150例。观察组患者采用右美托咪定进行全麻,对照组患者应用生理盐水来辅助全麻,10 min后两组患者通过芬太尼、丙泊酚进行全麻诱导,评价两组患者的芬太尼和丙泊酚用量,麻醉后不同时间的心率(heart rate,HR)、平均动脉压(mean arterial pressure,MAP)以及不良反应。结果:观察组患者的芬太尼用量、丙泊酚用量均少于对照组患者(P<0.05)。在T_0、T_2、T_4时,两组患者的HR、MAP比较,差异无统计学意义(P>0.05)。在T_1及T_3时观察组患者的HR、MAP均低于对照组患者(P<0.05)。观察组患者总不良反应发生率低于对照组患者(χ~2=4.624,P=0.032)。结论:在全麻中应用右美托咪定的镇痛效果和镇静效果较好,利于血流动力学的稳定,且安全性高,应推广使用。

Objective：To explore the application effect of dexmedetomidine in general anesthesia. Methods：300 cases of patients who underwent surgery in the hospital from March 2016 to April 2017 were selected and randomly divided into group A and group B, 150 cases in each group. The group A adopted dexmedetomidine for general anesthesia, and the group B used saline to assist anesthesia. 10 min later, fentanyl and propofol were used for anesthesia induction. The fentanyl and propofol dosages were compared, and HR, MAP and adverse reactions at different times were evaluated. Results ：The dosages of fentanyl and pmpofol in group A were less than those in group B （ P 〈 0.05 ）. At the To, T2 and T4 , there were no significant differences of HR and MAP in the two groups （ P 〉 0.05 ）. At the T1 and T3 , HR and MAP in group A were less than those in group B （ P 〈0.05）. The overall incidence of adverse reactions in group A was less than that in group B （Х^2 =4.624, P =0.032）. Conclusion：The analgesic and sedative effects of dexmedetomidine in general anesthesia are obvious, which is favorable for hemodynamic stability and highly secure. It should be popularized.