肝癌病理诊断中肝组织雌激素受体α表达的分析

Analysis of Hepatic Tissue Estrogen-receptor α Expression in Pathological Diagnosis of Hepatocellular Carcinoma

目的分析探讨肝癌病理诊断中肝组织雌激素受体α表达的临床价值,进一步为临床诊治肝癌提供理论指导与依据。方法选择2012年10月-2015年9月在我院接受治疗的肝癌患者25例为此次研究实验组,选取同时期来院体检的25例患者为对照组,实验组患者取其肝癌组织和癌旁标本、对照组取其正常肝脏组织标本,采用免疫组化的方法对肝组织雌激素受体α进行检测,探讨其表达情况。结果经过检测并统计发现,正常肝脏组织的肝组织雌激素受体α相对表达量为56.5%,肝癌患者的癌旁组织相对表达量为10.4%,而肝癌变组织的相对表达量为0%。结论由结果可见,肝组织雌激素受体α的表达量能够将正常的肝组织和肝癌组织鉴别出来,并且可将肝癌组织和癌旁组织划分出来,临床意义突出,值得进一步推广和使用。

Objective To analyze and discuss the clinical value of estrogen receptor α expression in liver tissue in pathological diagnosis of liver cancer, so as to provide theoretical guidance and basis for clinical diagnosis and treatment of liver cancer. Methods 25 patients with liver cancer treated in our hospital from October 2012 to September -2015 were selected as the experimental group, 25 cases of physical examination at the same period were selected as control group. The expression of estrogen receptor α in liver tissue was detected by immunohistochemistry, that was studied. Results After the examination and statistics found that the normal liver tissue of liver tissue relative expression of estrogen receptor alpha 56.5%, hepatocellular carcinoma tissues relative expression was 10.4%, and the relative expression of hepatocellular carcinoma tissues was 0%. Conclusion The expression of estrogen receptor alpha in liver tissue can be identified in liver tissue and liver tissue of normal, and the liver tissue and paracancerous tissue division, to highlight the clinical significance, is worthy of further promotion and application.