动脉灌注大剂量亚叶酸钙和氟尿嘧啶用于晚期胃癌

Arterial Infusion High Dose Leucovorin And 5-Fluorouracil Treatment In The Advanced Gastric Cancer

目的 :评价动脉灌注大剂量亚叶酸钙和 5 -氟尿嘧啶对晚期胃癌的效果。方法 :对 30例晚期胃癌病人 ,采用介入方法对肿瘤供血动脉进行大剂量亚叶酸钙和 5 -氟尿嘧啶等化疗药物灌注 ,观察肿瘤体积变化及随访生存期 ,并与静脉给药化疗病人对照。结果 :实验组 CR(完全缓解 ) +PR(部分缓解 ) 5 6 .7%、 MR(微效 ) +SD(好转 ) 30 % ,对照组 CR +PR 16 .7%、MR +SD 30 % ;实验组 12、18和 2 4个月的生存率分别为 90 %、76 .7%和 5 0 % ,对照组分别为 6 6 .7%、6 0 %和 10 %。结论 :采用介入方法灌注大剂量亚叶酸钙和 5 -氟尿嘧啶为主的化疗药可使肿瘤缩小、明显提高晚期胃癌病人的生存率。

Objective To evaluate the efect of the leucovorin and 5 fluorouracial throug the arterial infusion on advanced gastric cancer.Methods: 30 patients with advanced gastric cancer were treated by arterial infusion hight dose leucovorin plus 5 fluorouracil and other chemotherapy,The tumor size and survival were studied. Results: On the response rate,the CR+PR were 56.7% and MR+SD were 30% in studied group,but the CR+PR were 16.7% and MR+SD were 30% in control .The 12?18and 24 month survival rates in the studied groups were 90%?76.7%and 50% respectively,In the control groups were 66.7%?60% and 10% respectively.Conclusion: Aterial infusion high dose leucovorin plus 5 flurouracial may decerase the tumor size and increase the survival of patients with advance gastric cancer.