甲胎蛋白异质体检测在肝癌诊断中的意义

Significance of detection of alpha-fetoprotein heteroplasmon in the diagnosis of liver cancer

目的研究甲胎蛋白异质体检测在肝癌诊断中的意义。方法选取2014年3月~2015年2月期间本院收治的30例肝癌患者作为本次的研究对象作为A组,另选取同期收治的肝硬化、慢性肝炎患者作为B、C组,各30例,并将三组患者的甲胎蛋白(AFP)总含量和甲胎蛋白异质体3(AFP-L3)在AFP的比例及阳性率进行比较。结果 A组肝癌患者的AFP总含量为(537.52±36.11)ng/m L,其AFP-L3在AFP的比例为(0.521±0.071)%,与B、C两组比较具有显著性差异(P<0.05)。且A组肝癌患者的AFP阳性率为86.67%,AFP-L3阳性率为70.00%,与B、C两组比较均有显著性差异(P<0.05)。结论甲胎蛋白、甲胎蛋白异质体等检测指标在肝癌诊断中的临床价值显著,临床中可依据甲胎蛋白、甲胎蛋白异质体等检测指标,以此为肝癌的确诊,为临床中制定医疗方案提供有力依据。

Objective To investigate and determine the significance of alpha-fetoprotein heteroplasmon in the diagnosis of liver cancer. Methods 30 patients with liver cancer admitted in our hospital from March 2014 to February 2015 were selected as the subjects and treated as group A, and cirrhosis and chronic hepatitis patients admitted in the same period were as group B（n=30）and group C（n=30）, respectively. The total content of alpha-fetoprotein（AFP）, the ratio of AFP-L3 to AFP and positive rate between the three groups were compared. Results The total content of AFP in group A was（537.52±36.11）ng/m L, and the ratio of AFP-L3 to AFP was（0.521±0.071）%, compared with that of group B and group C, which was significantly difference（P〈0.05）. The positive rate of AFP and AFP-L3 was 86.67% and 70.00%respectively in group A, compared with that of group B and group C, which was significantly difference（P〈0.05）. Conclusion The clinical value of detection indicators such as alpha-fetoprotein and alpha-fetoprotein heteroplasmon in the diagnosis of liver cancer is significant. The test indicators including alpha-fetoprotein, alpha-fetoprotein heteroplasmon are used to diagnose liver cancer clinically, which provide a strong basis for the clinical development of medical programs.