脑源性神经营养因子与缺血性卒中的研究进展被引量：3

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摘要时至今日,脑卒中仍是长期致残的首位原因,其中缺血性卒中约占87%,具有高发病率、高致残率、高复发率、高病死率和高额医疗花费的特点。脑源性神经营养因子（brain-derived neurotrophic factor,BDNF）是神经营养因子家族成员之一,主要由中枢神经元合成,广泛分布于成人大脑皮质区,也存在于部分皮层下区域和脊髓中,对维持正常大脑生理过程,调控树突分支和树突棘的形态、突触可塑性、长时程增强作用,以及调节下丘脑代谢方面起重要作用.而且,BDNF已显示出其在缺血性脑卒中后神经保护和促进恢复两方面的重要作用[2].

作者李珍珠潘玉君

机构地区哈尔滨医科大学第一临床医学院神经内科

出处《西南国防医药》 CAS 2017年第10期1136-1138,共3页 Medical Journal of National Defending Forces in Southwest China

基金神经科学国家重点实验室基金课题(SKLN-201402)

关键词脑源性神经营养因子缺血卒中进展

分类号 R743.3 [医药卫生—神经病学与精神病学]

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1高列花,郑芳,汪俊群,曾晓云.急性缺血性脑卒中患者脑源性神经营养因子基因多态性与预后的相关性[J].中国现代医学杂志,2015,25(20):63-67. 被引量：12

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