硫辛酸对慢性酒精性周围神经病同型半胱氨酸、超敏C反应蛋白及临床症状的作用

The effects of lipoic acid on inflammatory factors and prognosis of chronic alcoholic peripheral neuropathy

目的观察硫辛酸对慢性酒精性周围神经病(CAPN)的同型半胱氨酸(HCY)、超敏C反应蛋白(Hs-CRP)及临床症状的作用。方法将46例CAPN患者随机分为治疗组和对照组,治疗组给予硫辛酸静脉滴注,0.6 g/d;对照组给予甲钴胺注射液避光静脉滴注500 ug/d,连用14 d,比较两组患者治疗前、治疗后HCY及HsCRP及变化,并以神经系统症状评分,以评价其疗效。结果治疗后2组患者HCY及Hs-CRP水平明显降低,与治疗前比较,差异有统计学意(P<0.05),且治疗组Hs-CRP及Hs-CRP水平显著低于对照组,差异有统计学意义(P<0.05);治疗后两组临床症状评分均降低,与治疗前比较,差异有统计学意义(P<0.05),且治疗组临床症状评分显著低于对照组,差异有统计学意义(P<0.05)。治疗期间2组患者均未出现明显不良反应。结论硫辛酸可降低CAPN患者HCY及Hs-CRP水平,显著改善患者临床症状,值得应用及研究。

Objective To observe the effect of lipoic acid on homocysteine（ HCY）,hypersensitive C reactive protein（ Hs-CRP） and clinical symptoms of patients with chronic alcoholic peripheral neuropathy（ CAPN）. Methods 46 cases of CAPN patients were randomly divided into treatment group and control group,the treatment group was given intravenous injection of lipoic acid 0. 6g/d; the control group was given intravenous infusion of Mecobalamin injection light is 500ug/d. After 14 days treatment,to compare the changes of HCY and Hs-CRP in two groups,to evaluate the scores of nervous system symptoms and efficacy. Results After treatment,the levels of HCY and Hs-CRP in the two groups were significantly decreased,compared with before treatment,the difference was statistically significant（ P〈0. 05）,the levels of HCY and Hs-CRP in the treatment group were significantly lower than those in the control group,the difference was statistically significant（ P〈0. 05）. Compared with before treatment,the clinical symptoms of the two groups were reduced,the difference was statistically significant（ P〈0. 05）,and the treatment group clinical symptom score was significantly lower than the control group,the difference was statistically significant（ P〈0. 05） Conclusion Lipoic acid can reduce the level of HCY and Hs-CRP of CAPN patients,significantly improve the clinical symptoms of patients. It is beneficial to the prognosis,is worthy of large-scale application and research.