AMPK调控能量代谢研究进展

The progress of AMPK in energy metabolism

腺苷酸激活蛋白激酶(AMP-activated protein kinase,AMPK)作为重要的能量代谢激酶,广泛存在于真核生物,在能量代谢调控中起重要作用。肝脏激酶B1(Liver kinase B1,LKB1)和钙调素依赖蛋白激酶(Calmodulin-dependent protein kinasesβ,Ca MKKβ)可激活AMPK。激活的AMPK通过对脂肪、蛋白质和糖类代谢的调控维持体内能量平衡。另外,AMPK调控因子激活剂与抑制剂、细胞因子可通过上调或下调AMPK表达,调控能量物质代谢。

AMP-activated protein kinase（ AMPK） is widely existed in eukaryotes and has vital function in energy metabolism. AMPK could be activated by Liver kinase B1（ LKB1） and calmodulin-dependent protein kinases β（ Ca MKKβ）,and it regulates the metabolism of fat,protein and glucose to balance the energy metabolism. Moreover,activator,inhibitor and cytokines regulate energy metabolism through up-regulation or down-regulation of AMPK expression.