联用氟哌噻吨美利曲辛治疗餐后不适综合征合并睡眠情绪障碍患者的临床研究

Clinical Efficacy of Deanxit Combined with Conventional Therapy for postprandial Distress Syndrome with Sleep and Mood Disorder

目的评价联用氟哌噻吨美利曲辛治疗餐后不适综合征(PDS)合并睡眠情绪障碍的临床疗效。方法选取300例PDS合并睡眠情绪障碍患者,随机分为对照组(150例)和试验组(150例)。对照组予多潘立酮(10 mg,tid)、胃粘膜保护剂和安慰剂,试验组予多潘立酮(10 mg,tid)、胃粘膜保护剂及氟哌噻吨美利曲辛(1片,bid),均治疗8周。利用匹茨堡睡眠质量指数(PSQI)和焦虑自评量表(SAS)、抑郁自评量(SDS)评价患者睡眠、情绪改善情况。比较两组患者的消化道症状、睡眼和情绪评分。结果联用氟哌噻吨美利曲辛治疗8周可明显改善患者的消化道症状;与对照组相比,患者睡眠质量PSQI总分以及反映焦虑抑郁状态的SAS、SDS评分下降。结论氟哌噻吨美利曲辛联合多潘立酮对餐后不适综合征合并睡眠情绪障碍患者疗效优于对照组,是该类患者理想的治疗方案。

Objective To evaluate the therapeutic effect of Deanxit combined with conventional therapy on postprandial distress syndrome（ PDS） with sleep and mood disorder. Methods Three hundred cases of PDS were randomized into two groups,with 150 cases in each group. Domperidone,protective agents for gastric mucosa and placebo were given to the control group,whereas Deanxit combined with conventional therapy was given to the treatment group for 8 weeks.Gastrointestinal symptoms were compared between the two groups,and Pittshurgh Sleep Quality Index（ PSQI） scores,self rating depression scale（ SDS）,self rating anxiety scale（ SAS） were used to evaluate sleep and mood improvement.Results Deanxit combined with conventional therapy for 8 weeks significantly improved patients＇ gastrointestinal symptoms.The PSQI scores and scores of SAS and SDS which reflected anxiety and depression state were decreased significantly after treatment compared with the control group. Conclusion Deanxit combined with domperidone has better effects on PDS with sleep and mood disorder than in the control group.