BDNF和NMDAR在微波辐射对学习记忆影响中作用的研究进展

Research Advances in the Role of BDNF And NMDAR in Learning and Memory after Microwave Radiation

随着微波技术的广泛应用,其潜在危害日益引起关注。中枢神经系统是微波辐射最敏感靶部位之一,海马是哺乳类动物完成学习记忆功能的关键结构,学习记忆能力障碍是微波辐射致海马损伤的重要表现形式。脑源性神经营养因子(BDNF)能促进突触可塑性、改变脑内神经元的形态、促进树突和轴突的生长,还参与学习记忆的机制和长时程增强效应。N-甲基-D-天冬氨酸受体(NMDAR)是一种兴奋性氨基酸特异性受体,可调节神经的存活、树突和轴突结构发育及突触可塑性,还能影响神经元回路的形成和学习记忆的过程。本文主要就BDNF和NMDAR在微波辐射对学习记忆的影响及其机制的研究进展进行综述,以期为今后的相关研究提供科学依据。

With the wide appliation of microwave technology,its potential harm to humans is becoming a concern. The central nervous system is one of the most sensitive parts to microwave radiation. The hippocampus is a key structure where mammals complete the function of learning and memory,and the damage to the learning and memory function is also the most significant effect of microwave radiation on the hippocampus. Brain derived neurotrophic factor（ BDNF） can promote synaptic plasticity,change the configuration of neurons in the brain,and promote the growth of dendrites and axons. BDNF is also involved in the mechanism of learning and memory and enhances the effect of long-term potentiation（ LTP）. N-methyl-D-aspartate receptor（ NMDAR） is an excitatory amino acid receptor with specificity,which can not only adjust the nerve survival,development and synaptic plasticity,but also influence the formation of neuronal circuits and the process of learning and memory.In this paper,we review the role of BDNF and NMDAR in microwave radiation effects on learning and memory and research progress in order to contribute to related research in the future.