生长因子在脊髓损伤中应用的研究进展

Recent advances in the application of growth factors in spinal cord injury

近年来,脊髓损伤发病率逐年增加,越来越受到重视。生长因子可促进神经纤维及突触的再生,在治疗脊髓损伤和恢复神经功能方面具有重要作用。生长因子本身半衰期短,因此需要利用生长因子基因载体转染干细胞、纳米微粒包裹生长因子或生长因子结合生物相容性支架等方法治疗脊髓损伤。随着对生长因子研究的深入,应用单一的生长因子难以满足治疗脊髓损伤的需要,因此,探索多种生长因子的协同作用以期达到更好的治疗效果是今后的主要研究方向。本文对脑源性神经营养因子、神经营养因子3、神经生长因子、碱性成纤维细胞生长因子的应用及生长因子协同治疗进展等方面进行综述,以期提高生长因子对脊髓损伤后的治疗效果。

The incidence of spinal cord injury is increasing year by year, and more and more attentions have been paid.Growth factors can promote the regeneration of nerve fibers and synapses, and they also play an important role in thetreatment of spinal cord injury and the recovery of neurological function. The growth factor itself has a short half-life, so it isnecessary to use growth factor gene vectors to transfect stem cells and nanoparticles to deliver growth factors orbiocompatible scaffolds to support growth factors to treat spinal cord injuries. With the development of the research ongrowth factors, the application of single growth factor is difficult to meet the need of treatment to spinal cord injury. Toexplore the synergistic effect of various growth factors in order to achieve a better therapeutic effect is a promising researchdirection in the future. The purpose of this review is to summarize the therapeutic effects of growth factors on spinal cordinjury including brain-derived neurotrophic factor, neurotrophic factor 3, nerve growth factor, basic fibroblast growth factor and synergy therapy of growth factors.