脂蛋白相关磷脂酶A_2活性检测在评估心血管疾病风险中的临床应用价值

Clinical Application Significance of Detecting the Activity of Lipoprotein-associated Phospholipase A_2(Lp-PLA_2) for the Assessment of Cardiovascular Risks

目的探讨脂蛋白相关磷脂酶A2(Lp-PLA_2)活性检测在评估冠心病等心血管事件风险中的临床应用价值。方法行冠状动脉造影术确诊为冠心病93例为冠心病组(CAD组),并按冠状动脉病变数量分为一支病变组32例、二支病变组28例和三支(及以上)病变组33例。以体检健康者271例为正常对照组(Control组)。检测各组血清中的Lp-PLA_2活性水平,并进行统计学分析。结果 Control组中,男性的Lp-PLA_2活性水平要高于女性,两性间差异有统计学意义(P<0.01)。CAD组Lp-PLA_2活性水平显著高于Control组(P<0.01)。不同病变数量患者的Lp-PLA_2活性水平的差异无统计学意义(P>0.05)。CAD组患者血液中Lp-PLA_2活性水平与其他单一血脂指标和复合指标有相关性,且有统计学意义。结论Lp-PLA_2活性检测可用于评估心血管事件的风险。

Objective We aimed to investigate the clinical application significance of detecting the activity of lipoprotein - associated phospholipase A2 （ Lp - PLA2 ） for the assessment of cardiovascular risks. Methods 93 patients diagnosed coronary artery disease were enrolled as CAD group. Coronary angiograms were performed and the patients were divided into single - vessel disease subgroup （32 patients） , two - vessels disease subgroup （28 patients） and three - vessels （ or multiple - vessels） disease subgroup （33 patients） according to the number of arteries with stenosis. The control group included 271 healthy participants. Serum Lp - PLA2 activity levels were detected in both groups, and the results were analyzed statistically. Results In control group, the activity levels of Lp - PLA2 in males were higher than those in females and there were significant differences between two genders （P 〈0.01）. The activity levels of Lp - PLA2 in CAD group were significantly higher compared to those in control group （ P 〈 0. 01） . The activity levels of Lp - PLA2 in subgroups of CAD group were not positively correlated with the severity of coronary artery diseases （ the number of coronary artery stenosis） and there were no statistically differences among subgroups （ P 〉 0. 05 ）. The activity levels of Lp - PLA2 in patients of CAD group were correlated with other single or complex blood lipid biomarkers with statistical significance. Conclusion Detecting activity levels of Lp - PLA2 can be applied for the assessment of cardiovascular risks.