摘要
2型糖尿病(T2DM)是一种以胰岛素抵抗或胰岛β细胞分泌功能缺陷为特征的代谢性疾病。黄酮类化合物在预防和治疗2型糖尿病中发挥着重要作用,其作用靶点多、机制复杂,尚难完全阐明。因此,明确黄酮类单体化合物的作用机制十分重要。黄酮类化合物可作用于胰腺β细胞、肝细胞、脂肪细胞和骨骼肌细胞中的多个靶点和不同的信号通路。本文分类综述了近年来天然黄酮类化合物抗2型糖尿病作用及机制的研究进展。
Type 2 diabetes mellitus （T2DM） is a metabolic disease characterized by increased insulin resistance,impaired insulin secretion and β-cell dysfunction.Flavonoids have a positive impact on T2DM with a multi-target and complex mechanisms.Flavonoids can act on multiple targets and different signaling pathways in pancreatic beta cells,hepatocytes,adipocytes and skeletal muscle cells.In this study,the research progress on the molecular mechanisms of flavonoids from natural plants in the treatment of type 2 diabetes mellitus was reviewed.
出处
《天然产物研究与开发》
CAS
CSCD
北大核心
2017年第10期1805-1811,共7页
Natural Product Research and Development
基金
北京市科委十病十药研发项目(Z161100001816001)
