突出腰椎间盘组织中PGE2、IL-6的表达与临床病理特征的相关性分析

Expressions of PGE2 and IL-6 in protrusion of lumbar intervertebral disc and its correlation with clinicopathological characteristics

目的探讨前列腺素E2(PGE2)及白细胞介素-6(IL-6)在突出腰椎间盘组织中的表达及其与临床病理特征的关系。方法收集2016年1~12月80例腰椎间盘突出症患者(研究组)的突出椎间盘组织,同时选取同期胸腰椎骨折急诊手术青壮年患者40例(对照组)的正常间盘组织。采用免疫组化法分别检测PGE2、IL-6阳性表达情况,并分析PGE2、IL-6表达与腰椎间盘突出症患者临床病理特征之间的关系。结果研究组PGE2表达阳性率为56.3%,明显高于对照组2.5%(P<0.05)。研究组IL-6表达阳性率为63.8%,明显高于对照组2.5%(P<0.05)。研究组腰椎间盘突出症患者突出椎间盘组织中PGE2、IL-6阳性表达率均与痛视觉模拟评分(VAS)相关(P<0.05),均与年龄、节段及疼痛部位无关(P>0.05)。结论 PGE2、IL-6在突出椎间盘组织中呈高表达,且与腰椎间盘突出症患者临床腰腿VAS评分紧密相关;PGE2、IL-6指标表达升高可能参与腰椎间盘突出症患者的疼痛反应过程。

Objective To study the expressions of PGE2 and IL-6 in protrusion of lumbar intervertebral disc and its correlation with clinicopathological characteristics. Methods 80 patients with protrusion of lumbar intervertebral disc who were underwent operation in our hospital were selected as research group. At the same time,40 cases of young patients with thoracic and lumbar fractures were selected as control group.The expression of PGE2 and IL-6 in two groups were detected. Results The positive rate of PGE2 expression in lumbar intervertebral disc herniation group was 56. 3%,which was significantly higher than that in control group 2. 5%（ P〈0. 05）. The positive rate of IL-6 expression in lumbar intervertebral disc herniation group was 63. 8%,which was significantly higher than that in control group 2. 5%（ P〈0. 05）. The positive expression rates of PGE2 and IL-6 in the herniated intervertebral disc of the study group were correlated with the VAS score（ P〈0. 05）,which had nothing to do with age,segment and pain site（ P〈0. 05）. Conclusion The high expression of PGE2 and IL-6 in intervertebral disc tissues,and lumbar disc herniation patients with lumbocrural pain visual analogue scale（ VAS） is closely related to PGE2; the index of IL-6 and increase the expression may be involved in lumbar disc herniation pain reaction process.