美沙拉嗪与微生态制剂联合治疗对溃疡性结肠炎患者凝血功能及TLR5、NF-κB的影响

Influence of mesalazine combined with microecological preparation on the coagulation parameters and expression of TLR5 and NF-κB in the treatment of patients with ulcerative colitis

目的探讨美沙拉嗪与微生态制剂联合治疗对溃疡性结肠炎患者凝血功能及Toll样受体-5(TLR5)、核因子κB(NF-κB)的影响。方法选取2014年12月至2015年12月收治的110例溃疡性结肠炎患者为研究对象,根据随机数字表法分为对照组和观察组,各55例。对照组给予美沙拉嗪治疗,观察组在对照组的基础上联用微生态制剂(双岐杆菌三联活菌)。所有患者均连续治疗2个月,分析比较两组患者治疗前后的临床疗效、Sutherland DAI评分、凝血指标以及TLR5和NF-κB表达情况。结果观察组患者治疗总有效率(94.5%)明显高于对照组(72.7%),差异具有统计学意义(P<0.05);治疗后观察组与对照组的Sutherland DAI评分比治疗前均有显著降低,且观察组治疗后的Sutherland DAI评分显著优于对照组(P<0.05);治疗后两组TLR5和NF-κB阳性表达率均呈不同程度降低,而观察组TLR5和NF-κB阳性表达率明显低于对照组(P<0.05);治疗后两组平均血小板体积(MPV)、凝血酶原时间(PT)水平均呈不同程度增高,而血小板计数(PLT)和纤维蛋白原(FIB)水平呈不同程度降低,且治疗后观察组患者的凝血功能指标显著优于对照组(P<0.05);两组患者不良反应发生率无显著差异(P>0.05)。结论美沙拉嗪与微生态制剂联合治疗对溃疡性结肠炎效果显著,能明显改善患者临床症状和凝血功能,同时能够有效降低TLR5、NF-κB的表达水平,值得临床上推广应用。

Objective To explore the influence of mesalazine combined with microecological preparation on the coagulation parameters and expression of TLR5 and NF-κB in the treatment of patients with ulcerative colitis. Methods 110 cases of patients with ulcerative colitis from March 2014 to March 2015 were selected as the research object,all of them were randomly divided into control group（ 55 cases） and observation group（ 55 cases）. The control group was given amlazapine treatment. The observation group was given microecological preparation（ bifico） on that basis of the control group. After 2 month of treatment,the clinical efficacy,Sutherland DAI score,coagulation parameters,expression of TLR5 and NF-κB and complications between the two groups were analyzed and compared. Results 2 month after the treatment,the overall effective treatment rate of study group were 94. 5%,control group were 72. 7%,the efficiency of the former was significantly higher than the latter（ P〈0. 05）. Compared with before treatment,the Sutherland DAI score had decreased after treatment in both groups,while the Sutherland DAI score of the observation group were lower than that of control group（ P〈0. 05）; Compared with the before treatment,the positive rates of TLR5 and NF-κB had increased to varying degrees after treatment in both groups,while the positive rates of TLR5 and NF-κB of the observation group was lower（ P〈0. 05）. After the treatment,the level of PLT and FIB had decreased to varying degrees,while the levels of MPV and PT had significantly increased,and the levels of MPV and PT in observation group were higher than those of control group,the level of PLT and FIB were significantly lower in control group（ P〈0. 05）. No difference were found in complications rate between control group and observation group during the treatment. Conclusion The implementation of mesalazine combined with microecological preparation treatment for patients with Diabetic peripheral neuropathy is significantly effective,it can significantly improve the patients＇ clinical symptoms and the coagulation function,decrease the expression of TLR5 and NF-κB,worthy of promotion.