四种辅助治疗用于IB1～IIB期宫颈癌患者根治术后的疗效分析

Analysis on curative effect of four kinds of adjuvant therapy for patients with stage IB1～IIB cervical cancer after radical operation

目的分析四种辅助治疗用于IB1~IIB期宫颈癌患者根治术后的疗效。方法选取2015年1月至2017年1月收治的80例IB1~IIB期宫颈癌根治术后的患者,依据辅助治疗方法将这些患者分为多西他赛联合奥沙利铂组(A组,n=20)、多西他赛联合顺铂组(B组,n=20)、紫杉醇联合顺铂组(C组,n=20)和长春新碱联合博来霉素联合顺铂组(D组,n=20)四组,对四组患者的临床疗效、毒副作用发生情况进行统计分析。结果四组患者的总缓解率80.0%(16/20)、70.0%(14/20)、65.0%(13/40)、60.0%(12/40)之间的差异无显著性(P>0.05);A组患者的胃肠反应、神经毒性、白细胞减少发生率均显著低于B组、C组、D组(P<0.05)。结论多西他赛联合奥沙利铂辅助治疗用于IB1~IIB期宫颈癌患者根治术后疗效优于多西他赛联合顺铂、紫杉醇联合顺铂和长春新碱联合博来霉素联合顺铂,值得临床推广应用。

Objective To analyze the curative effect of four kinds of adjuvant therapy for patients with stage IB1 ～ IIB cervical cancer after radical operation. Methods 80 patients with stage IB1 ～ IIB cervical cancer after radical operation in this hospital during January 2015 to January2017 were selected for this study,all of them were divided into docetaxel combined with oxaliplatin group（ group A,n = 20）,docetaxel combined with cisplatin group（ group B,n = 20） and paclitaxel combined with cisplatin group（ group C,n = 20） and vincristine and bleomycin combined with cisplatin group（ group D,n = 20） four groups on the basis of adjuvant therapy,the efficacy,incidence rates of adverse reactions of patients in these four groups were statistically analyzed. Results The difference in total remission rate among these four groups [80. 0 %（ 16/20） ],[70. 0%（ 14/20） ],[65. 0%（ 13/40） ]and[60. 0%（ 12/40） ]was not significant（ P〈0. 05）. The incidence rates of gastrointestinal reactions,neurotoxicity and neutropenia in group A were significantly lower than those of group B,group C and group D（ P〈0. 05）. Conclusion The efficacy of docetaxel combined with oxaliplatin adjuvant therapy for patients with stage IB1 ～ IIB cervical cancer after radical operation is better than that of docetaxel combined with cisplatin,paclitaxel combined with cisplatin and vincristine combined with bleomycin and cisplatin,hence it is worthy to be promoted.