术后辅助不同放化疗方案对高级别胶质瘤患者的预后分析

The prognostic of high-grade glioma patients in post-operation for different chemoradiotherapy in adjuvant treatment

目的分析术后辅助放化疗对高级别胶质瘤(HGG)患者生存期的影响。方法选择手术切除且经病理证实为HGG的患者81例,其中术后辅助替莫唑胺(TMZ)同步放化疗及6个疗程标准化疗(Stupp方案)患者42例,Stupp方案后TMZ继续化疗39例。分析术后不同放化疗方案对患者生存期的临床疗效。结果 Stupp方案后继续化疗组平均生存期31.87个月较Stupp方案化疗组平均生存期24.38个月长(P=0.002),差异有统计学意义。TMZ化疗的不良反应主要发生在前6周期,延长化疗周期并未增加化疗毒性。结论 Stupp方案化疗结束后继续化疗可以延长HGG患者的总生存期(OS)。

Objective To analyzed the influence of different adjuvant chemoradiotherapy treatment strategies for high-grade glioma( HGG) patients after operation. Methods Selected eighty-one HGG patients proved by pathology. Forty-two cases received post-operative radiotherapy accompanied with chemotherapy and the later of 6 cycles groups chemotherapy( Stupp protocol). Thirty-nine cases was more than 6 cycles groups,to evaluated the curative effect of the two groups survival time. Results The chemotherapy protocol of more than 6 cycles groups average overall survival( OS) was 31. 87 months more than 6 cycles groups 24. 38 mouths( P = 0. 002). It had significant difference between the two group. TMZ toxicity was mainly occurred in 6 cycles. No obvious adverse reaction was observed in long-term chemotherapy. Conclusions Continued chemotherapy when the 6 cycles groups finished can increasing the average survival time of HGG patients.