松龄血脉康胶囊干预大鼠动脉粥样硬化的作用及机制

Effect and Mechanism of Songling Xuemaikang Capsule on Atherosclerosis Rats

正常大鼠饲喂高脂饲料配合腹腔注射维生素D3建立AS(动脉粥样硬化)大鼠模型。将实验大鼠随机分为正常组(A组)、模型组(B组)、松龄血脉康胶囊低(0.6 g·kg^(-1)·d^(-1),C组)、高(1 g·kg^(-1)·d^(-1),D组)剂量组、阳性对照辛伐他汀组(10 mg·kg^(-1)·d^(-1),E组)。12周后腹主动脉取血检测各组血脂;酶联免疫吸附法测定各组血清超敏C反应蛋白、白介素6及单核细胞趋化蛋白1含量。12周后与B组相比,D组可以显著降低血脂(TC、LDL)(P<0.05)并使血清超敏C反应蛋白及白介素6含量显著下降(P<0.01);C组、D组血清单核细胞趋化蛋白1含量显著下降(P<0.05,P<0.01)。松龄血脉康胶囊可通过降低AS大鼠血脂;降低血清超敏C反应蛋白、单核细胞趋化蛋白1、白介素6的水平,减轻炎症反应,阻止AS发展。

Normal rats were fed with high lipid feedstuff to set up atherosclerosis rat model. The rats were randomly divided into 5 groups of A（ normal rats）,B（ atherosclerosis rats）,C（ atherosclerosis rats fed with Songling Xuemaikang Capsule 0. 6 g·kg^（-1）·d^（-1））,D（ atherosclerosis rats fed with Songling Xuemaikang Capsule 1 g·kg^（-1）·d^（-1）） and E（ atherosclerosis rats fed with Simvastatin 10 mg·kg^（-1）·d^（-1））. After 12 weeks,the lipid indexes,hsCRP,IL-6,MCP^（-1） in serum of each group rats were measured. The main blood lipid indexes（ TC,LDL） in group of D was lower than those in group B（ P 0. 05）. Hs-CRP and IL-6 had decreased significantly（ P 0. 01） in group of D after 12 weeks. MCP^（-1） had decreased significantly（ P 0. 05,P 0. 01） in group of C and D. Songling Xuemaikang capsule could intervene with experimental atherosclerotic development in rats,which mechanism might be that Songling Xuemaikang capsule could suppressive the main indexes（ TC,LDL） and reduce inflammation reactions.