帕瑞昔布钠预防瑞芬太尼麻醉术后痛觉过敏的临床观察

The clinical observation of parecoxib sodium in the prevention of hyperalgesia induced by remifentanyl anesthesia after operation

目的:探讨帕瑞昔布钠预防瑞芬太尼麻醉术后痛觉过敏的临床效果。方法:将行腹腔镜胆囊切除术病人106例按照抽签法分为对照组和观察组,各53例,对照组行常规麻醉,观察组在对照组基础上使用帕瑞昔布钠,对比2组不同时间点心率(HR)及平均动脉压(MAP)、疼痛视觉模拟评分(VAS),意识恢复时间及拔管时间,不良反应情况。结果:观察组T_1、T_2、T_3时间点HR及MAP均低于对照组(P<0.05~P<0.01);2组病人在T_1、T_2、T_3时刻的VAS评分均有上升(P<0.01),但观察组上升幅度低于对照组(P<0.01);2组病人意识恢复时间、拔管时间以及不良反应率差异均无统计学意义(P>0.05)。结论:帕瑞昔布钠预防瑞芬太尼麻醉术后痛觉过敏的效果肯定,值得推广。

Objective：To observe the clinical effects of parecoxib sodium in the prevention of hyperalgesia induced by remifentanyl anesthesia after operation. Methods：One hundred and six patients treated with laparoscopic cholecystectomy were divided into the control group and observation group according to the draw method（53 cases each group）. The control group and observation group were treated with routine anesthesia and parecoxib sodium based on the control group,respectively. The heart rate（HR） of different time points,mean arterial pressure（MAP）,score of visual analogue scale（VAS）,consciousness recovery time,extubation time and adverse reactions between two groups were compared. Results：The HR and MAP of observation group at T1 ,T2 and T3 were lower than those of control group（P〈0. 05 to P〈0. 01） The VAS scores in two groups at T1,T2 and T3 increased（P〈0. 01）,and the increasing degree of which in observation group was lower than that in control group（P〈0. 01）,and the differences of the recovery time,extubation time and incidence rate of adverse reaction between two groups were not statistically significant（P〉0. 05）. Conclusions：The clinical effect of parecoxib sodium in the prevention of hyperalgesia induced by remifentanyl anesthesia after operation is good, which is worthy of promotion.