脂肪酸从头合成代谢重编程与肿瘤的发生发展

Metabolic reprogramming of the de novo fatty acid synthesis pathway in cancer development and progression

肿瘤细胞代谢重编程是肿瘤发生发展过程中最显著的特征之一,是对肿瘤有氧糖酵解(即Warburg效应)内涵的进一步扩展。细胞癌变过程的代谢模式发生显著变化,涉及到糖酵解、氧化磷酸化、氨基酸代谢、脂肪酸代谢和核酸代谢等诸多方面,其中脂肪酸代谢在肿瘤细胞的能量存储、细胞增殖及重要信号分子合成等方面起到重要作用。研究脂肪酸从头合成代谢的机制与肿瘤发生发展的关系,利用、干预和修正代谢通路上关键酶的异常,正成为肿瘤诊断、预防和治疗的新思路。本文就脂肪酸从头合成代谢重编程与肿瘤发生发展的关系做一综述。

Cancer cell metabolic reprogramming is a highly significant feature in tumor development and progression. This process is an extension of aerobic glycolysis（i.e., Warburg effect）. The metabolic pattern, such as that of glycolysis, oxidative phosphorylation,amino acid metabolism, fatty acid metabolism, and nucleic acid metabolism, is altered significantly during cell carcinogenesis. Fatty acid metabolism is required for energy storage, membrane proliferation, and signaling molecule generation. Thus, studying the mechanism of de novo fatty acid synthesis and its relationship with the development and progression of tumor, as well as the use and targeting of the key enzyme in this metabolic pathway, is vital for the diagnosis, prevention, and treatment of cancer. Herein, we provide a brief review of metabolic reprogramming in cancer cells. We focus on the pathways of de novo fatty acid synthesis during the development and progression of tumor.