免疫细胞的脂肪酸代谢与肿瘤免疫

Fatty acid metabolism of immune cells and tumor immunity

免疫细胞代谢是一个新兴的研究领域,旨在解析关键代谢途径对于免疫细胞发育、增殖和功能的影响。近年来,该领域取得了许多重要的研究成果。本文将聚焦肿瘤中脂肪酸代谢和免疫细胞功能相关的最新进展,阐述脂肪酸代谢通路中代谢物变化是如何在肿瘤微环境中精准调节免疫细胞的发育、分化和功能,解析肿瘤中免疫细胞功能的代谢调节机制,为肿瘤的免疫学作用及其机制研究提供新的思路和方法。

Immunometabolism is a burgeoning field that aims toexplore the contribution of key metabolic path- ways to immune cell development, differentiation, and function. In recent years, a substantial number of important achievements have been made in this area. Here, we focus on the latest findings related to fatty acid metabolism and immune cell functions in tumor, providing a general framework for understanding how fatty acid metabolism fuels and regulates the immune responses. By giving specific examples, this review will illustrate how the metabolites changes infatty acid metabolic pathway precisely modulate the development, differentiation and functioning of im- mune cellsandexplore the metabolic regulation mechanisms of immune cells in tumor micro-environment, to pro- vide new methods and insights for studyingthe immunity mechanism in tumor.