补体系统及其糖基化

Complement and Glycosylation

补体系统是固有免疫系统的重要组成部分,同时也是连接固有免疫和适应性免疫系统的重要桥梁.补体系统由30多种蛋白质组成,且其中绝大多数都经过糖基化修饰.近年来对补体系统的研究,不断揭示出补体系统在抗击病原微生物入侵和维持有机体生理稳态过程中发挥着重要作用.然而补体系统需要严格的调控,不论是激活不足、抑或是过度激活都可能引起疾病的发生.本文概述了近年来对于补体系统的激活、调控和功能研究的最新进展,并首次从糖生物学角度对补体系统蛋白质组分的糖链结构及糖链对相应蛋白质功能的影响进行了综述和小结.

Complement system is an essential part of the innate immunity which serves as a bridge between innate and adaptive immunity. The complement system comprises of over 30 different proteins, most of which are glycoproteins. The recent researches have shown that complement system plays important roles in defense against the evading microbes and maintaining the cellular hemostasis. However, the complement system requires firm controls. Either insufficient activation or over-activation of complement would cause diseases. In this review, we summarize the recent advances in understanding the activation, regulation and the function of complement system and for the first time review the complement system by its glycosylation： we summarize the glycan structures of the complement proteins and analyze the glycosylation impact on the function of the proteins.