植物蛋白O-GlcNAc糖基化及生物学功能

Research Advances in Plants Protein O-GlcNAcylation

蛋白质的O-GlcNAc糖基化现象发现迄今已有30多年历史.动物中,O-GlcNAc糖基化在调控细胞信号转导、基因转录、表观遗传和新陈代谢等方面发挥重要作用.而植物中,O-GlcNAc糖基化在近几年才得到关注并进行初步研究.本文对植物中O-GlcNAc修饰的糖供体合成途径、O-GlcNAc修饰关键酶、O-GlcNAc修饰蛋白的检测及功能等方面的研究工作进行归纳总结,发现O-GlcNAc糖基化在植物的生长发育、激素网络调控、信号转导、植物病毒侵染等过程均发挥重要作用,为进一步研究植物中O-GlcNAc糖基化的生物学功能提供参考.

The phenomenon of protein O-GlcNAcylation has been discovered for more than 30 years. In animals,O-GlcNAcylation plays important roles in cellular signaling transduction, gene transcription, epigenetic,metabolism regulation and etc. While the functions of O-GlcNAcylation in plants is remain unclear, and only few studies were reported in recent years. In this review paper, the research advances on plants O-GlcNAcylation were reviewed, including UDP-Glc NAc biosynthesis pathway, the key enzymes in O-GlcNAc modification pathway, the detection and function analysis of O-GlcNAc modified proteins. These works revealed that O-GlcNAcylation has essential functions in plant growth and development, plant hormone networks regulation, signal transduction and plant virus infection process. This article will facilitate the subsequent research on the O-GlcNAcylation in plants.