miRNA-1在高血压左心室肥厚诊断中的价值

The value of microRNA-1in the diagnosis of hypertensive left ventricular hypertrophy

目的:探讨miRNA-1在高血压左心室肥厚诊断中的价值,为获取心脏疾病相关信息提供新的方法和途径。方法:收集210例入住我院心内科的患者,其中70例为高血压合并左室肥厚组(HBP-LVH组)、70例为高血压不合并左室肥厚组(HBP-NLVH组),以及70例门诊随机选择健康体检者为对照组,所有入选患者完善一般临床资料、常规检查,心脏超声检查测定室间隔厚度(IVSd)与左室后壁厚度(LVPWd)。收集血浆后用qRTPCR检测miRNA-1的表达。结果:与对照组和HBP-NLVH组比较,HBP组的IVSd、LVPWd、miRNA-1显著升高,差异具有统计学意义(均P<0.05)。血浆miRNA-1在LVH诊断中的敏感度和特异度分别为94.6%和89.8%。miRNA-1水平与IVSd和LVPWd均表现为正相关,相关系数R分别为0.64和0.66。结论:miRNA-1在高血压左心室肥厚患者的外周循环血浆中特异性高表达,且与左心室肥厚呈正相关,诊断左心室肥厚有很好的敏感度和特异度。

Objective：To study the value of microRNA-1（miR-1）in the diagnosis of hypertensive left ventricular hypertrophy,and to provide new ways and means to obtain related information for heart disease.Method：Two hundred and ten cases were collected,including 70 cases of hypertension with left ventricular hypertrophy group（HBP-LVH group）,70 cases hypertension without left ventricular hypertrophy group（HBP-NLVH group）and 70 cases physically health people.General clinical data of all patients were recorded.Then all patients received regular check and cardiac ultrasound measurement for IVSd and LVPWd.The expression of MiR-1was checked by qRT-PCR after collecting the plasma.Result：IVSd,LVPWd and MiR-1were significant higher in the HBPLVH group（P〈0.05）than in the control group.The sensitivity and specificity of plasma MiR-1in the diagnosis of LVH were respectively 94.6% and 89.8%.MiR-1level had a positive correlation with IVSd and LVPWd,and the correlation coefficient R is respectively 0.64 and 0.66（P=0.000）.Conclusion：MiR-1is highly expressed in the peripheral circulation of patients with hypertensive left ventricular hypertrophy,and is positively related to left ventricular hypertrophy.MiR-1has good sensitivity and specificity for the diagnosis of LVH.