锰的雄性生殖毒性研究进展

Research advance on reproductive toxicity of manganese in males

锰是一种自然界广泛存在的金属元素,是人体必需的微量元素,被大量应用于农业、工业生产中。近年来,越来越多的研究表明,锰具有雄性生殖毒性,表现为损害睾丸组织,降低精子数量及活力,诱导生殖细胞凋亡,改变酶活性,干扰生殖激素水平等。本文综述锰的暴露途径、锰对雄性生殖系统的影响及毒性机制,建议根据锰诱导生殖细胞凋亡展开通路相关机制研究,为锰的雄性生殖损伤防治提供依据。

Manganese is a metal element widely existing in nature and an essential trace element for human body. It is heavily used in agricultural and industrial production. Recent studies suggest effects of manganese on male reproductive toxicity. It can damage testis tissue, decrease sperm number and vitality, induce apoptosis of germ cells, alter enzyme activity, and interfere with reproductive hormone levels. Manganese exposure routes, effects on male reproductive system, and related mechanisms were reviewed in this article. It is suggested that the signaling pathway related mechanism of manganese induced apoptosis in germ cells should be studied in order to provide evidence for the prevention and treatment of male reproductive damage caused by manganese.