circRNA与疾病研究进展

Research progress on circRNA and diseases

环状RNA(circular RNA,circRNA)不同于传统的线性RNA,是一类共价闭合环状的非编码RNA,广泛存在于生物体中,具有稳定、广泛的组织特异性表达。其特殊的分子结构使其具有充当miRNA"海绵"、调节转录或剪接、与RNA结合蛋白相互作用等功能,还可作为疾病诊断的生物标志。本文从circRNA的形成、分类、功能及其与疾病、与环境和表观遗传学的关系等方面进行综述,可为circRNA在疾病研究、诊断和治疗中的应用提供参考。

Circular RNA（circ RNA）, unlike traditional linear RNA, is a type of covalently closed circular non-coding RNA, which widely exists in organisms and often exhibits high stability, abundance, and tissue-specific expression. Its special molecular structure allows it acting as mi RNA sponges, regulating transcription or splicing, and interacting with RNA binding proteins. circ RNA can be used as a biomarker for the purpose of disease diagnosis. This article reviewed the formation, classification, and function of circ RNA, its relationship with diseases, and the potential effects of environment and epigenetics, aiming to provide new ideas for circ RNA applied in disease study, diagnosis, and treatment.