细胞焦亡与牙龈卟啉单胞菌的关系及其在牙周病发生发展中的作用机制

Mechanism of pyroptosis and Porphyromonas gingivalis in periodontitis development process

细胞焦亡是一种典型的程序性细胞死亡方式,主要通过炎症小体的介导,并伴有大量促炎性细胞因子的释放。牙龈卟啉单胞菌作为牙周炎的关键致病菌,一方面可通过激活牙周组织中巨噬细胞内核苷酸结合寡聚化结构域样受体蛋白3炎症小体,促进细胞焦亡,引发牙周组织免疫病理损伤;另一方面,牙龈卟啉单胞菌通过抑制血管内皮细胞焦亡,逃逸免疫系统的杀伤作用,促进自身生存。本文就细胞焦亡及其在牙周炎中的作用机制作一综述。

Pyroptosis is a typical form of programmed cell death mediated by inflammasomes. It leads to inflammatory response through the release of pro-inflammatory cytokines. Porphyromonas gingivalis is the keystone pathogen of periodontitis. On the one hand, it can activate the nucleotide-binding oligomerization domain like receptor protein 3 inflammasomes of macrophages in the periodontal tissue, and it also can promote pyroptosis that lead to the immune pathological damage of periodontal tissue; on the other hand, it restrain the pyroptosis of vascular endothelial cell and escape the killing of the immune system. In this paper, the recent progress and mechanism of pyroptosis in periodontitis are reviewed.