酰胺质子转移成像的临床应用及挑战

Clinical application and challenges of amide proton transfer imaging

近年来,酰胺质子转移(Amide proton transfer,APT)成像作为一种新的MR成像方法 ,在临床应用中得到越来越多的关注。APT成像技术能够通过水信号变化探测体内游离蛋白质、多肽的酰胺质子与水质子的化学交换特征,可从分子水平上反映脑发育、脑肿瘤、中风、新生儿缺氧缺血脑病等组织内蛋白质及(或)p H的变化。目前APT成像除神经系统外,在多个系统中也得到应用。APT成像作为一种在体、无创、无需外源性对比剂的细胞分子水平MR成像技术,能够为临床提供更多的信息,会在今后的研究中得到进一步发展。

In recent years, amide proton transfer（APT） imaging, as a new modality of MR imaging, has attracted more and more attention in clinical applications. APT imaging can detect the exchange characteristics of amide protons in free proteins and peptides and water protons by means of water signal changes. APT imaging can reflect tumor, stroke, neonatal hypoxicischemic encephalopathy related to protein and pH at the molecular level. In addition to the nervous system, APT imaging has now been used in several other systems. APT imaging, as an in vivo, noninvasive, cellular and molecular level MR imaging modality without exogenous contrast agents, can provide more information for clinical studies and will be further developed in future studies.