有氧运动联合曲美他嗪对稳定型心绞痛患者左室收缩功能的影响

Aerobic exercise combined with trimetazidine can improve the left ventricle＇s systolic function in angina patients

目的 观察有氧运动联合曲美他嗪（TMZ）对稳定型心绞痛患者左心室收缩功能的影响。 方法 选取2015年6月至2016年6月期间在河北医科大学第四医院心内科治疗的稳定型心绞痛患者73例，采用随机数字表法将上述患者分为观察组、药物组及对照组，3组患者均给予常规内科药物治疗，药物组同时给予TMZ口服，观察组则同时辅以TMZ口服及有氧运动训练。于治疗前、治疗3个月后分别检测各组患者左室收缩功能改善情况，同时记录各组患者硝酸甘油使用量及心绞痛发作次数。 结果 治疗前各组患者硝酸甘油使用量、心绞痛发作次数及左室收缩功能指标组间差异均无统计学意义（P〉0.05）。治疗3个月后发现观察组患者左室收缩功能较治疗前、对照组及药物组均明显改善（P〈0.05），心绞痛发作次数及硝酸甘油使用量较治疗前、对照组及药物组均明显减少（P〈0.05）。 结论 在常规药物治疗稳定型心绞痛基础上辅以TMZ及有氧运动训练，能进一步改善患者左心室功能，对缓解病情及降低心血管疾病发生风险具有重要意义。

Objective To observe the impact of aerobic exercise combined with trimetazidine （TMZ） on the left ventricle′s systolic function among stable angina patients. Methods Seventy-three stable angina patients treated in the Cardiology Department of the Fourth Hospital of Hebei Medical University between June 2015 and June 2016, were selected and randomly divided into an observation group, a medicine group and a control group. All three groups were given routine drug therapy, while the medicine group and observation group were additionally provided with TMZ, and TMZ combined with aerobic exercise respectively for 3 months. Nitroglycerin consumption, angina attacks and left ventricular systolic function were recorded before and after the treatment. Results Before the treatment there were no significant differences in average nitroglycerin consumption, the frequency of angina attacks or left ventricular systolic function among the three groups. After the 3 months of treatment, left ventricular systolic function in theobservation group had improved significantly on average compared with before treatment and with the other two groups after the treatment. Nitroglycerin consumption and angina attacks were significantly less as well. Conclusion Aerobic exercise combined with TMZ can significantly improve the left ventricular function of stable angina patients, which is of great significance for alleviating their condition and reducing the incidence of cardiovascular disease.