摘要
目的:探讨胰激肽原酶肠溶片联合西地那非治疗高海拔地区2型糖尿病合并勃起功能障碍(ED)患者的安全性及疗效。方法:选择青海西宁地区糖尿病合并ED患者93例,随机分成两组,试验组(48例)服用胰激肽原酶肠溶片(120 u,3次/d)联合小剂量西地那非规律服用(25 mg,每晚1次),对照组(45例)小剂量西地那非规律服用(25 mg,每晚1次),两组治疗4、8周后评价两组阴茎彩色多普勒超声(CDDU)检查、国际勃起功能指数(IIEF-5)、性交满意度。结果:患者年龄及糖尿病病程两组间均无显著差异(P>0.05)。治疗4周:试验组和对照组治疗前后IIEF-5评分[(8.81±2.06)分vs(11.54±7.72)分和(8.29±1.91)分vs(9.37±1.65)分]、SIS[(3.35±2.43)分vs(6.83±2.61)分和(3.41±2.38)分vs(4.92±2.49)分]、CDDU均有显著差异(P<0.05),两组间IIEF-5评分[(11.54±7.72)分vs(9.37±1.65)分]和SIS[(6.83±2.61)分vs(4.92±2.49)分]有显著差异(P<0.05),而CDDU参数无差异(P>0.05)。治疗8周:试验组和对照组治疗前后IIEF-5评分[(8.81±2.06)分vs(19.29±1.85)分和(8.29±1.91)分vs(15.43±1.74)分]均有显著差异(P<0.05),两组间IIEF-5评分[(19.29±1.85)分vs(15.43±1.74)分]、SIS[(11.73±2.57)分vs(6.55±2.71)分]、CDDU参数均有显著差异(P<0.05)。结论:胰激肽原酶肠溶片联合西地那非治疗高海拔地区2型糖尿病合并ED患者具有一定临床疗效,且较单一西地那非治疗更为有效。
Objective: To investigate the safety and efficacy of pancreatic kininogenase combined with sildenafil in the treatment of erectile dysfunction( ED) in type 2 diabetes mellitus( DM) patients in the high-altitude area. Methods: This study included93 ED patients with type 2 DM,all residents of the Xining area 1500 meters above sea level. We randomly divided them into an experimental group( n = 48) and a control group( n = 45),the former treated with pancreatic kininogenase( 120 u,tid) and sildenafil( 25 mg,qd at bedtime),while the latter with sildenafil only( 25 mg,qd at bedtime). After 4 and 8 weeks of medication,we obtained the penile hemodynamic parameters,IIEF-5 scores,and sexual intercourse satisfaction( SIS) scores and compared them between the two groups of patients. Results: There were no statistically significant differences in age or DM course between the two groups of patients( P 〈0. 05). Compared with the baseline,both the experimental and control groups showed remarkably improvement inthe IIEF-5 score( 8. 81 ± 2. 06 vs 11. 54 ± 7. 72 and 8. 29 ± 1. 91 vs 9. 37 ± 1. 65,P 〈0. 05),SIS score( 3. 35 ± 2. 43 vs6. 83 ± 2. 61 and 3. 41± 2. 38 vs 4. 92 ± 2. 49,P 〈0. 05),and penile hemodynamic parameters obtained by color duplex Doppler ultrasonography( P 〈0. 05),with significant differences between the two groups in the IIEF-5 score( 11. 54 ± 7. 72 vs 9. 37 ± 1. 65,P 〈0. 05) and SIS score( 6. 83 ± 2. 61 vs 4. 92 ± 2. 49,P 〈0. 05) but not in the penile hemodynamic parameters( P 〈0. 05). Even more remarkable improvement was observed at 8 weeks in the experimental and control groups in the IIEF-5 score( 19. 29 ± 1. 85 and 15. 43 ± 1. 74)( P 〈0. 05),SIS score( 11. 73 ± 2. 57 and 6. 55 ± 2. 71)( P 〈0. 05),and penile hemodynamic parameters( P 〈0. 05),all with significant differences between the two groups( P 〈0. 05). Conclusion: Pancreatic kininogenase combined with sildenafil has a better clinical effect than sildenafil alone on ED in type 2 DM patientsin the high-altitude area.
出处
《中华男科学杂志》
CAS
CSCD
北大核心
2017年第10期878-882,共5页
National Journal of Andrology
基金
全军医药卫生科研基金(CLZ11JB09)
兰州军区高原攻关课题(LZ13GY01)~~