食欲素受体拮抗剂治疗失眠

New methods to treat insomnia-orexin receptor antagonists

目的为治疗失眠症新方法即食欲素受体拮抗剂的深入研究及临床运用提供参考。方法通过web of knowledge、scifinder和pubmed等外文数据库查阅相关文献44篇并对其进行分析与总结。结果现有的治疗方法包括认知行为治疗法(cognitive-behavioral therapy,CBT-I)和药物治疗两大类。由于CBT-I法需花费大量的时间和精力而药物干预法存在许多不良反应,所以在临床中运用都受限。近年来研究发现食欲体系可调节睡眠-醒觉体系,食欲素拮抗剂是一类新型的治疗失眠症的药物且副作用小,现已有大批量的食欲素受体拮抗剂用于失眠的研究。结论食欲素受体拮抗剂是治疗失眠的一类新方法。

Objective provide a reference for further research and clinical application of orexin receptor antagonists which are new methods for treatment of insomnia. Methods Through a web of knowledge, scif＇mder, pubmed and other foreign language database to consult with 44 references and carries on the analysis and summary. Results The existing treatment for insomnia consists of cognitive behavior therapy （CBT-I） and pharmacological therapy. Since CBT-I need to spend a lot of time and energy and pharmacological interventions are associated with many adverse reactions, it is used in clinical are limited. In recent years, the study found that orexin system can adjust the sleep-wake system, orexin antagonists are a new class of drugs for treating insomnia with small side effects, now large quantities of orexin receptor antagonists are used in the study of insomnia. Conclusions Orexin receptor antagonists are a class of new methods to treat insomnia.