乳腺Paget's病发病机制的研究进展

Advances in pathogenesis of breast Paget's disease

乳腺Paget's病是乳腺癌的一种罕见形式,由James Paget's于1874年提出。有关乳腺Paget's病的发病机制一直备受争议,目前最主要的两种理论是嗜表皮理论和转化理论。近年来,随着对乳腺Paget's病发病机制的研究又提出了一些新的假说:因子受体学说、内分泌学说及病毒学说。乳腺Paget's病的治疗方法主要包括改良根治术、单纯乳腺切除术、保乳术等外科手术治疗,根据术后病理辅以放化疗。对于那些有强烈保乳或整形意愿的患者可给予光动力疗法进行新辅助治疗。本文通过对近几年的相关文献的阅读及整理对乳腺Paget's病发病机制的相关理论和假说进行综述。

Breast paget＇s disease is a rare form of breast cancer,proposed by James Paget＇s in 1874. The pathogenesis of Paget＇s disease has been controversial; there are two main theories are epiphytic theory and transformation theory. In recent years,with the pathogenesis of breast Paget＇s disease development,some new hypotheses are input such as factor and receptor theory,endocrine theory and virus theory. Breast Paget＇s treatment methods include improved radical surgery,simple breast resection,breast conserving surgery and other surgical treatment,according postoperative pathology combined with radiotherapy and chemotherapy. For those who have strong breast protection or plastic surgery will be given to patients with photodynamic therapy for neoadjuvant therapy.This paper reviews the relevant theories and hypotheses about the pathogenesis of mammary gland by collecting related literatures in recent years.