法舒地尔联合α-硫辛酸治疗阳痿可行性及安全性评价

Feasibility and Safety of Fasudil Combined with α-Lipoic Acid for Treating Impotence

目的研究法舒地尔联合α-硫辛酸治疗阳痿的可行性及安全性。方法选择首次诊断阳痿患者84例,随机分为对照组和观察组,各42例。对照组采用西地那非口服,每次50 mg,1天1次,持续3周;观察组联合法舒地尔10μg溶于100 mL 0.9%氯化钠注射液和α-硫辛酸600 mg溶于0.9%氯化钠注射液250 mL静脉滴注,1天1次,持续3周;对比两组的疗效及不良反应。结果治疗3周后,两组的阴茎勃起功能障碍国际指数(IIEF-5)问卷表评分和阴茎勃起硬度比较,差异无统计学意义(P>0.05);随访3个月和6个月,观察组的IIEF-5评分和阴茎勃起硬度均明显高于对照组,差异有统计学意义(P<0.05);随访6个月,观察组的总有效率显著高于对照组,差异有统计学意义(P<0.05);两组均未出现严重不良反应。结论法舒地尔联合α-硫辛酸治疗阳痿,有效性及安全性均较好。

Objective To study the feasibility and safety of fasudil combined with α-lipoic acid for treating impotence. Methods A total of 84 patients with impotence diagnosed for the first time were randomly divided into the control group and the observation group, 42 cases in each group. The control group was given sildenafil orally,50 mg per time,1 d/time for 3 weeks,while the observation group was given 10 μg fasudil ＋ 100 mL 0. 9% Sodium Chloride Injection combined with 600 mg α-lipoic acid＋250 mL 0. 9%Sodium Chloride Injection,ivgtt,1 d/time for 3 weeks. The efficacy and adverse reaction of the two groups were compared. Results Af-ter 3 weeks of treatment,there was no significant difference in the IIEF-5 scores and the hardness of penile erection between the two groups （P 〉 0. 05）,after 3 months and 6 months follow-up,the IIEF-5 score and the hardness of penile erection of the observation group were significantly higher than those of the control group（P 〈 0. 05）. After 6 months follow-up,the total effective rate of the observation group was significantly higher than that of the control group （P 〈 0. 05）,and there was no serious complication in the two groups. Conclusion Fasudil combined with α-lipoic acid for treating impotence has good effect and safety.