可达龙预防冠状动脉旁路移植术后室性心律失常临床评价

Clinical Evaluation of Cordarone for Preventing Ventricular Arrhythmias After Coronary Artery Bypass Grafting

目的观察可达龙用于冠状动脉旁路移植术后预防室性心律失常的临床疗效。方法选取2013年10月至2016年12月收治的实施冠状动脉旁路移植术患者112例,按随机数字表法分为观察组和对照组,各56例。对照组患者应用常规药物治疗,观察组患者应用可达龙治疗。结果观察组患者收缩压为(120.5±2.3)mmHg,舒张压为(76.1±5.5)mmHg,心率为(62.7±7.5)次/分,重症监护室(ICU)监护时间为(1.8±0.5)d,住院时间为(11.6±2.4)d,室性心律失常发生率为14.29%,分别明显低于对照组的(123.8±2.1)mmHg,(80.9±5.3)mmHg,(70.5±8.0)次/分,(3.0±1.4)d,(17.6±3.2)d和42.86%(P<0.05),且神经内分泌因子水平、心功能改善明显优于对照组(P<0.05)。结论可达龙预防冠状动脉旁路移植术后室性心律失常疗效显著,既可改善神经内分泌因素水平及心功能,又可降低临床指标,降低室性心律失常发生率,值得临床推广。

Objective To observe the effect of Cordarone for preventing ventricular arrhythmias after coronary artery bypass grafting. Methods A total of 112 patients underwent coronary artery bypass grafting were selected and divided into the observation group and the control group by random number table method,56 cases in each group. The control group was treated with conventional medicine, while the observation group was treated with Cordarone. Results The systolic blood pressure,diastolic blood pressure,heart rate,ICU monitoring time,hospital stay,the incidence rate of arrhythmia in the observation group were （120. 5 ± 2. 3）mmHg,（76. 1 ± 5. 5）mmHg, （62. 7 ± 7. 5）bpm,（1. 8 ± 0. 5）d,（11. 6 ± 2. 4）d and 14. 29%,respectively,which were significantly lower than （123. 8 ± 2. 1）mmHg, （80. 9 ± 5. 3）mmHg,（70. 5 ± 8. 0）bpm,（3. 0 ± 1. 4）d,（17. 6 ± 3. 2）d and 42. 86% in the control group （P 〈 0. 05）. The levels of neuroendocrine factors and cardiac function in the observation group were obviously better than those in the control group （P 〈 0. 05）. Conclusion Cordarone for preventing ventricular arrhythmias after coronary artery bypass grafting has good effect,it can not only improve the level of neuroendocrine factors and cardiac function,but also reduce the clinical indicators and the incidence of ventricular arrhythmia,which is worthy of clinical promotion.