继发性长QT综合征与尖端扭转型室性心动过速

Acquired long-QT syndrome and torsade de pointes

长QT综合征(long-QT syndrome,LQTS)为心室复极时程延长、不均一性及离散度增大的一种疾病,其危险性在于尖端扭转型室性心动过速(torsade de pointes,Td P)、心室颤动的发生,临床表现为晕厥、搐搦或猝死。LQTS包括遗传性长QT综合征(c LQTS)和继发性长QT综合征(aLQTS),a LQTS在临床工作中较cLQTS更为常见,具有潜在致命性,是院内心源性猝死的重要原因之一。在推荐的QT/QTc间期延长的临界值范围内,利用不同的QT/QTc间期计算方法,尽量准确评估心室复极,可预测TdP并进一步降低猝死率。

Long-QT syndrome（ LQTS） is characterized by prolongation of ventricular repolarization time,and increase of inhomogeneity and dispersion.LQTS is dangerous because it may lead to torsade de pointes（ Td P） and ventricular fibrillation.The clinical manifestations include syncope,tetany or sudden death.LQTS includes congenital long-QT syndrome（ c LQTS） and acquired long-QT syndrome（ a LQTS）.The latter is more frequently seen in clinical practice than the former,and is potentially lethal,which makes it one of the most important reasons for sudden cardiac death in hospital.In the calculation of QT / QTc intervals,to evaluate ventricular repolarization as accurately as possible in different methods within the recommended range of critical value of QT / QTc interval prolongation time can predict the occurrence of Td P and further reduce the rate of sudden death.