骨化三醇冲击对尿毒性继发性甲状旁腺功能亢进的影响

Effect of Calcitriol Impulse Therapy in Treatment of Uremia Secondary Hyperparathyroidism

目的:研究骨化三醇冲击对尿毒性继发性甲状旁腺功能亢进的影响。方法:将60例尿毒症继发性甲状旁腺功能亢进患者分为对照组(n=30例)和治疗组(n=30例)两组。对照组行骨化三醇常规治疗,治疗组患者行骨化三醇冲击治疗,治疗12周后比较两组患者血清钙(Ca)、磷(P)和甲状旁腺激素(PTH)变化情况。结果:治疗有效率比较,治疗组比对照组更高;两组治疗后血钙浓度、血磷浓度和i PTH浓度比较,差异具有统计学意义(P<0.05)。对照组治疗前后血钙浓度、血磷浓度和i PTH浓度比较,差异无统计学意义(P>0.05)。治疗组治疗前后血钙浓度、血磷浓度和i PTH浓度比较,差异具有统计学意义(P<0.05)。结论:骨化三醇冲击较常规治疗组对尿毒症继发性甲状旁腺功能亢进取得良好的治疗效果,且安全,值得基层医院推广应用。

Objective To observe the effect of calcitriol impulse therapy in the treatment of uremia secondary hyperparathyroidism. Method The 60 uremic patients with maintenance hemodialysis were divided into the treatment group（ n = 30） and the control group（ n = 30） randomly. Patients in control group were given routine therapy with calcitriol. Patients in treatment group were given impulse therapy with calcitriol. All patients were treated continuously for 12 weeks; the level of serum calcium（ Ca）,phosphorus（ P）,intact parathyroid hormone（ i PTH） of the two groups were compared,the clinical efficacy and adverse reations of two groups were evaluated. Results The effective rate of the treatment group was higher than that of the control group; The concentration of serum calcium,serum phosphorus and i PTH were compared between the two groups after treatment with significant difference（ P〈 0. 05）,that of the control group before and after treatment with no significant difference（ P〉0. 05）. Conclusion The clinical efficacy of calcitriol impulse therapy in the treatment of uremia secondary hyperparathyroidism is effective and safety,it is worth to be popularized and applied in primahy hospital.