摘要
分别以3-羟基丙腈和甲醇为原料合成氯维地平的两个杂质CLP-D和CLP-E,并经核磁共振氢谱、核磁共振碳谱和质谱确证其结构。两种杂质的总收率分别是12.80%和12.91%。该合成路线有利于氯维地平的质量控制。
Two impurities of clevidipine butyrate CLP-D and CLP-E were synthesized from 3-hydroxypropionitrile and methanol and the structures of the two impurities were confirmed by1 H-NMR,13 C-NMR and Mass Spectrometry（ MS）. The yields were 12. 80% and 12. 91% respectively. The synthetic method could be helpful for the quality control of clevidipine butyrate.
出处
《化工时刊》
CAS
2017年第9期14-17,共4页
Chemical Industry Times
基金
江苏省大学生科研创新项目:201510298106X
关键词
氯维地平
杂质
化学合成
结构表征
Clevidipine butyrate
Impurity
Chemical synthesis
Structural characterization
