摘要
干细胞(stem cell)是一类可自我复制的多潜能细胞。目前发现,通过体外诱导多种干细胞可分化为肝样细胞,并有肝细胞的表面标记及功能。肝移植为终末期肝病的最有效治疗方式,但面临供肝不足、费用大、长期免疫治疗等诸多限制。因此,干细胞在治疗终末期肝病方面显现出潜在的应用价值。文章重点综述干细胞分化为类肝细胞的调控机制进展。
Stem cells have the potential for self-renewal and multi-directional differentiation. Experiments have proven that stem cells can differentiate into hepatocyte-like cells under certain conditions, with hepatocyte markers and functions. Liver transplantation is the only effective and curative way for end-stage liver disease, but is limited by a shortage of donor organs,high costs of surgery,long-term immune therapy,and so on. In light of that, stem cells are of potential application value in the treatment of end-stage liver disease. This review focused on the regulatory mechanisms of stem cells differentiated into hepatocyte-like cells.
出处
《外科研究与新技术》
2017年第3期189-192,197,共5页
Surgical Research and New Technique
关键词
干细胞
分化
调节机制
肝细胞
Stem cells
Differentiation
Regulatory mechanism
Hepatocyte-like cells
