绝经后女性精神分裂症患者血脂正常组与异常组甲状腺与性激素水平比较

Comparison of thyroid and sex hormone levels in normal menstrual and elevated groups of postmenopausal women with schizophrenia

目的:探讨绝经后女性精神分裂症患者血脂正常组与异常组的甲状腺激素与性激素水平的变化。方法:选取绝经后女性精神分裂症患者76例,分别检测血清胆固醇(TC)、甘油三酯(TG)及甲状腺激素:游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺素(TSH);性激素:泌乳素(PRL)、雌二醇(E2)、孕酮(P)、睾酮(To)、促卵泡生成素(FSH)、黄体生成素(LH)水平。结果:76例绝经后女性精神分裂症中,血脂升高患者26例(34.21%),血清性激素水平异常者62例(81.58%),甲状腺激素异常者8例(10.53%);与血脂正常组相比,血脂异常组泌乳素浓度明显增高,FT3水平明显降低(P均<0.05)。结论:绝经后女性精神分裂症患者血脂代谢异常的发生率高,且可能与泌乳素、甲状腺激素水平有关。

Objective：To detect the levels of blood lipid,and their relationship with the level of serum thyroid hormone and sex hormone in menopausal women with schizophrenia.Methods：The levels of TC,TG,serum thyroid hormone and sex hormone were tested in 76 menopausal women with schizophrenia.Results：The abnormal rates of blood lipid,sex hormone and serum thyroid hormone were 34.21%,81.58% and 0.53% respectively.The level of serum FT3 in hyperlipemia group was significantly lower than that in normal blood lipid group,and the level of serum prolact was significantly higher than that in normal blood lipid group.Conclusion：The abnormality rate of blood lipid are higher in menopausal women with schizophrenia,which may relate to the level of and thyroid hormone.