左甲状腺素治疗甲状腺功能减退症合并妊娠的疗效研究

Levothyroxine treatment of hypothyroidism combined pregnancy

目的:探究左甲状腺素治疗甲状腺功能减退症合并妊娠患者的疗效。方法:收集诊断为甲状腺功能减退症的妊娠妇女30例为观察组,给予口服左甲状腺素(优甲乐)治疗,对比分析患者治疗前和治疗后甲状腺功能相关指标的差异;随机选取30例正常人为正常组,比较患者的妊娠结局和妊娠并发症的发生情况与正常组之间的差异。结果:患者治疗后促甲状腺激素(TSH)较治疗前明显降低,游离四碘甲状原氨酸(fT4)明显升高,差异有统计学意义(P<0.05),其他甲状腺功能指标治疗前后差异无统计学意义(P>0.05);活产率和妊娠并发症的发生率与正常组比较差异无统计学意义(P>0.05)。结论:左甲状腺素治疗甲状腺功能减退症合并妊娠有较好的疗效,能明显提高患者甲状腺功能,同时能改善患者的妊娠结局和甲状腺功能低下引起妊娠并发症的风险。

Objective：To explore the effect of levothyroxine treating patients with hypothyroidism and pregnancy.Methods：Collected 30 patients with hypothyroidism and pregnancy as the experimental group and gave them levothyroxine（Euthyrox）treatment,compared the difference of thyroid-related indicators before and after treatment.Selected 30 cases of normal people randomly as the normal group,then compared the the difference of pregnancy outcomes and the occurrence of pregnancy complications between the experimental group and the normal group.Results：Patients＇ thyroid stimulating hormone（TSH）reduced,free four iodine thyroid original amino acid（fT4）increased after treatment.The difference was statistically significant（P〈0.05）.The difference of other thyroid-related indexes were not statistically significant before and after treatment（P〉0.05）.Live birth rate and the incidence of pregnancy complications was not significant difference between normal group and experimental group（P〉0.05）.Conclusions：Levothyroxine treatment of hypothyroidism pregnancy patients was curative.The treatment can significantly improve patients＇ thyroid function and pregnancy outcome.At the same time,the treatment can reduce the risk of pregnancy complications caused by hypothyroidism.